HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)-3-nitropyridine → tert-butyl(S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)-3-nitropyridine | HCID 69095957 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-butyl(S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine | HCID 86669191 | 67% |
Reaction Steps
Following Method 2 of Example 49, (S)-4-(3-(tert-butyl dimethylsilyloxy)piperidin-1-yl)-3-nitropyridine in ethanol was reduced yielding tert-butyl (S)-4-(3-(tert-butyldimethylsilyloxy)piperidin-1-yl)pyridin-3-amine (67% yield 3 steps). LCMS (m/z): 308.2 (MH+); LC Rt=3.47 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9d19944cd6754ea090aceaabf9c44164 |
| Source note | uspto-grants-2014_09 |