HRID69943

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2N)C1

HCID59332360

tert-Butyl [(3S)-1-(3-aminopyridin-4-yl)piperidin-3-yl]carbamate

C15H24N4O2

HCID70700873

6-Bromo-3-fluoropyridine-2-carboxylic acid

C6H3BrFNO2

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2NC(=O)c2nc(Br)ccc2F)C1

HCID86669197

未命名化合物

PROCEDURE

实验过程

Following Method 11 (Example 305), (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate was coupled to 6-bromo-3-fluoropicolinic acid yielding (S)-tert-butyl 1-(3-(6-bromo-3-fluoropicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate which was used directly as is. LCMS (m/z): 496.2 (MH+); LC Rt=2.71 min.