HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-tert-Butyl (1-(3-aminopyridin-4-yl)piperidin-3-yl)carbamate → (S)-tert-butyl 1-(3-(6-bromo-3-fluoropicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-tert-Butyl (1-(3-aminopyridin-4-yl)piperidin-3-yl)carbamate | HCID 59332360 | — |
| Reactant | 6-Bromo-3-fluoropyridine-2-carboxylic acid | HCID 70700873 | — |
| Product | (S)-tert-butyl 1-(3-(6-bromo-3-fluoropicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate | HCID 86669197 | — |
Reaction Steps
Following Method 11 (Example 305), (S)-tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate was coupled to 6-bromo-3-fluoropicolinic acid yielding (S)-tert-butyl 1-(3-(6-bromo-3-fluoropicolinamido)pyridin-4-yl)piperidin-3-ylcarbamate which was used directly as is. LCMS (m/z): 496.2 (MH+); LC Rt=2.71 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7660074806db41c981aeba5b7d95048f |
| Source note | uspto-grants-2014_09 |