HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-6-chloro-2-methylthiopyrimidine → 6-chloro-N,N-di-BOC-2-(methyl-thio)pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-6-chloro-2-methylthiopyrimidine | HCID 70496 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 6-chloro-N,N-di-BOC-2-(methyl-thio)pyrimidin-4-amine | HCID 86669199 | — |
Reaction Steps
Method 24 was followed using 6-chloro-2-(methylthio)pyrimidin-4-amine (1.0 equiv.), BOC2O (2.0 equiv.), and DMAP (cat.) to afford 6-chloro-N,N-di-BOC-2-(methylthio)pyrimidin-4-amine in >95%. LCMS (m/z): 376.1 (MH+); LC Rt=4.9 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-686d47d587ce4c5ebc3d4b2afe3d07dc |
| Source note | uspto-grants-2014_09 |