Dichloromethane → 3-((4-(4-Amino-3-fluorobenzoyl)piperazin-1-yl)methyl)-N-(3,3-difluorocyclobutyl)benzamide
Reaction equation
[CH2:41]([P:42]([OH:43])(=[O:44])[OH:45])[CH2:46][CH3:47].[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[Cl:48][CH2:49][Cl:50].[F:1][C:2]1([F:22])[CH2:3][CH:4]([NH:6][C:7]([c:8]2[cH:9][c:10]([CH2:14][N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[cH:11][cH:12][cH:13]2)=[O:21])[CH2:5]1.[NH2:23][c:24]1[c:25]([F:33])[cH:26][c:27]([C:28](=[O:29])[OH:30])[cH:31][cH:32]1>>[F:1][C:2]1([F:22])[CH2:3][CH:4]([NH:6][C:7]([c:8]2[cH:9][c:10]([CH2:14][N:15]3[CH2:16][CH2:17][N:18]([C:28]([c:27]4[cH:26][c:25]([F:33])[c:24]([NH2:23])[cH:32][cH:31]4)=[O:29])[CH2:19][CH2:20]3)[cH:11][cH:12][cH:13]2)=[O:21])[CH2:5]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-4f89b5502a424f0a8e8fe1136bbaf204
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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