Hydroxide → 4-(3-Dimethylaminoazetidin-1-yl)piperidine-1-carboxylic acid [4-(4-aminophenoxy)pyridin-2-yl]amide

HRID 700440Notes

Reaction equation

HRID 700440 reaction equation
[C+4:38].[N+:1]([O-:2])(=[O:3])[c:4]1[cH:5][cH:6][c:7]([O:8][c:9]2[cH:10][c:11]([NH:15][C:16](=[O:17])[N:18]3[CH2:19][CH2:20][CH:21]([N:24]4[CH2:25][CH:26]([N:28]([CH3:29])[CH3:30])[CH2:27]4)[CH2:22][CH2:23]3)[n:12][cH:13][cH:14]2)[cH:31][cH:32]1.[O:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1.[OH-:39].[OH-:41].[OH-:42].[OH-:43].[OH-:44].[OH-:45].[Pd+2:40]>>[NH2:1][c:4]1[cH:5][cH:6][c:7]([O:8][c:9]2[cH:10][c:11]([NH:15][C:16](=[O:17])[N:18]3[CH2:19][CH2:20][CH:21]([N:24]4[CH2:25][CH:26]([N:28]([CH3:29])[CH3:30])[CH2:27]4)[CH2:22][CH2:23]3)[n:12][cH:13][cH:14]2)[cH:31][cH:32]1

Participants

6

Reactant 5

HCID 961Hydroxide6×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 576773934-[3-(Dimethylamino)azetidin-1-yl]piperidine-1-carboxylic acid [4-(4-nitrophenoxy)pyridin-2-yl]amideHCID 178420935HCID 178420935, compound

Product 1

HCID 576773374-(3-Dimethylaminoazetidin-1-yl)piperidine-1-carboxylic acid [4-(4-aminophenoxy)pyridin-2-yl]amide

Sources & evidence

ORD record
ord-1377e9092e27487d863867b1090c7310
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

Loading…