Tetrahydrofuran → 8-(2-Cyclopropyl-2-hydroxy-ethanesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:1][S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([c:14]3[cH:15][cH:16][c:17]([O:20][C:21]([F:22])([F:23])[F:24])[cH:18][cH:19]3)[C:12]2=[O:13])[CH2:25][CH2:26]1.[CH3:27][CH2:28][CH2:29][CH2:30][Li:31].[CH:32]1([CH:35]=[O:36])[CH2:33][CH2:34]1>>[CH2:1]([S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([c:14]3[cH:15][cH:16][c:17]([O:20][C:21]([F:22])([F:23])[F:24])[cH:18][cH:19]3)[C:12]2=[O:13])[CH2:25][CH2:26]1)[CH:35]([CH:32]1[CH2:33][CH2:34]1)[OH:36]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-97838ecf75144632a612938af7584701
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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