反应详情

温度

80 °C

533 mg 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine, 850 mg (R)-1-amino-1-(4-fluoro-phenyl)-2-methyl-propan-2-ol and 1.3 ml diisopropylethylamine are suspended in 9.8 ml dioxane. The reaction mixture is stirred for 2 hours in the microwave at 80° C. and then evaporated to dryness. The residue is mixed with water. The precipitate formed is suction filtered and purified by chromatography (silica gel, petroleum ether/ethyl acetate 100/0 to 60/40). 260 mg of the product are obtained as a solid.

1. customevaporated to dryness
2. additionThe residue is mixed with water
3. customThe precipitate formed
4. filtrationfiltered
5. custompurified by chromatography (silica gel, petroleum ether/ethyl acetate 100/0 to 60/40)