(S)-5-dibenzylamino-1-methylpiperidin-2-one → HCID 28064098, compound

HRID 70092Notes

Reaction equation

HRID 70092 reaction equation
C([N:8](CC1C=CC=CC=1)[C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C@@H:9]1[CH2:14][N:13]([CH3:15])[C:12](=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 1

HCID 59708472(S)-5-dibenzylamino-1-methylpiperidin-2-one

Product 1

HCID 28064098HCID 28064098, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

450 mg (S)-5-dibenzylamino-1-methyl-piperidin-2-one are suspended in 25 ml of methanol and hydrogenated with 150 mg Pd/C 10% under a pressure of 3 bar and at a temperature of 60° C. After 16 hours the catalyst is removed by suction filtering and the filtrate is evaporated to dryness. 190 mg of the product are obtained as an oil.

Workup

  1. customAfter 16 hours the catalyst is removed by suction
  2. filtrationfiltering
  3. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-361341bef66e4e7bbc5870aec89c9a28
Source dataset
uspto-grants-2014_09
Patent number
US08822474B2

Reaction notes

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