反应详情

温度

180 °C

20.45 g 1-(4-chloro-phenyl)-piperazine are placed in 5.95 ml (104 mmol) glacial acetic acid and heated to 180° C. 8.01 g 2-methylsulphanyl-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ol are added, the non-stirrable reaction mixture is heated for 2.5 hours to 180° C. After cooling, water is added, the precipitate is suction filtered and dried in the air. The substance is treated with ethanol under ultrasound, suction filtered and dried. 12.95 g of the product are obtained as a powder.

1. temperaturethe non-stirrable reaction mixture is heated for 2.5 hours to 180° C
2. temperatureAfter cooling
3. filtrationfiltered
4. customdried in the air
5. additionThe substance is treated with ethanol under ultrasound, suction
6. filtrationfiltered
7. customdried