Triphenylphosphine → 2-amino-4-(1,1-difluoro-ethyl)-5-(2-methyl-2H-pyrazol-3-yl)-benzoic acid methyl ester
Reaction equation
[CH3:17][n:18]1[n:19][cH:20][cH:21][c:22]1[Sn:23]([CH2:24][CH2:25][CH2:26][CH3:27])([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:32][CH2:33][CH2:34][CH3:35].[CH3:1][O:2][C:3]([c:4]1[c:5]([NH2:15])[cH:6][c:7]([C:11]([CH3:12])([F:13])[F:14])[c:8]([I:10])[cH:9]1)=[O:16].[O:36]1[CH2:37][CH2:38][O:39][CH2:40][CH2:41]1.[Pd:42]([Cl:43])[Cl:44].[c:45]1([P:46]([c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[cH:59][cH:60][cH:61][cH:62][cH:63]1.[c:64]1([P:65]([c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[c:72]2[cH:73][cH:74][cH:75][cH:76][cH:77]2)[cH:78][cH:79][cH:80][cH:81][cH:82]1>>[CH3:1][O:2][C:3]([c:4]1[c:5]([NH2:15])[cH:6][c:7]([C:11]([CH3:12])([F:13])[F:14])[c:8](-[c:22]2[n:18]([CH3:17])[n:19][cH:20][cH:21]2)[cH:9]1)=[O:16]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-f4441e8dcea748caa979e46ef7fd3840
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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