反应详情

温度

60 °C

18.5 potassium phthalimide are suspended in 50 ml DMF, the mixture is heated to 60° C. and 16.5 g methyl 4-chloro-3-methoxy-but-2-enoate in 50 ml DMF are added. After 2 days the reaction mixture is poured into 500 ml of water. The precipitate formed is suction filtered and washed with water. The residue is dissolved in ethyl acetate, dried and the solution is evaporated to dryness. The residue is triturated with ether. 21.77 g of the product are obtained as a powder.

1. customThe precipitate formed
2. filtrationfiltered
3. washwashed with water
4. dissolutionThe residue is dissolved in ethyl acetate
5. customdried
6. customthe solution is evaporated to dryness
7. customThe residue is triturated with ether