Dimethylformamide → 2-(4-amino-3-chloro-phenyl)-1-cyclobutyl-6-(pyrimidin-2-yloxy)-1H-indole-3-carbonitrile

HRID 701288Notes

Reaction equation

HRID 701288 reaction equation
[C:32](=[O:33])([O-:34])[O-:35].[Cl:25][c:26]1[n:27][cH:28][cH:29][cH:30][n:31]1.[Cs+:36].[Cs+:37].[NH2:1][c:2]1[c:3]([Cl:24])[cH:4][c:5](-[c:8]2[n:9]([CH:20]3[CH2:21][CH2:22][CH2:23]3)[c:10]3[cH:11][c:12]([OH:19])[cH:13][cH:14][c:15]3[c:16]2[C:17]#[N:18])[cH:6][cH:7]1.[O:38]=[CH:39][N:40]([CH3:41])[CH3:42]>>[NH2:1][c:2]1[c:3]([Cl:24])[cH:4][c:5](-[c:8]2[n:9]([CH:20]3[CH2:21][CH2:22][CH2:23]3)[c:10]3[cH:11][c:12]([O:19][c:26]4[n:27][cH:28][cH:29][cH:30][n:31]4)[cH:13][cH:14][c:15]3[c:16]2[C:17]#[N:18])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 744042-ChloropyrimidineHCID 104967Cesium cation2×HCID 594306152-(4-amino-3-chloro-phenyl)-1-cyclobutyl-6-hydroxy-1H-indole-3-carbonitrile

Product 1

HCID 594306702-(4-amino-3-chloro-phenyl)-1-cyclobutyl-6-(pyrimidin-2-yloxy)-1H-indole-3-carbonitrile

Sources & evidence

ORD record
ord-1527742467c94504800121ec205bd02b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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