反应详情

4 M HCl in 1,4-dioxane (6 mL, 24 mmol) was added to 4-tert-butyl 1-benzyl 2-((pyridin-3-yloxy)methyl)piperazine-1,4-dicarboxylate (77 mg, 0.18 mmol). After 12 h, the reaction mixture was concentrated under reduced pressure, dissolved in water, and basified with 1 N NaOH in water. The solution was extracted with EtOAc (3×), and the combined organics were dried over Na2SO4, filtered, and concentrated under reduced pressure. This gave 40.5 mg (69%) of the title compound. LC-MS: RT=5.15 min, [M+H]+=328.1.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. dissolutiondissolved in water
3. extractionThe solution was extracted with EtOAc (3×)
4. dry with materialthe combined organics were dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure