Acetate → Methyl 6-(3,4-dimethoxyphenyl)pyridine-2-carboxylate

HRID 702032Notes

Reaction equation

HRID 702032 reaction equation
[C:51]([O-:52])(=[O:53])[CH3:54].[C:56]([O-:57])(=[O:58])[CH3:59].[CH2:61]([CH2:62][O:63][CH3:64])[O:65][CH3:66].[CH3:12][O:13][c:14]1[cH:15][c:16]([O:22][B:23]([OH:24])[OH:25])[cH:17][cH:18][c:19]1[O:20][CH3:21].[Cl:1][c:2]1[cH:3][cH:4][cH:5][c:6]([C:8](=[O:9])[O:10][CH3:11])[n:7]1.[Na+:45].[Na+:46].[O-:47][C:48](=[O:49])[O-:50].[OH2:60].[Pd+2:55].[c:26]1([P:27]([c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[cH:40][cH:41][cH:42][cH:43][cH:44]1>>[c:2]1(-[c:16]2[cH:15][c:14]([O:13][CH3:12])[c:19]([O:20][CH3:21])[cH:18][cH:17]2)[cH:3][cH:4][cH:5][c:6]([C:8](=[O:9])[O:10][CH3:11])[n:7]1

Participants

10

Reactant 9

HCID 175Acetate2×HCID 923Sodium ion2×HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 11776TriphenylphosphineHCID 19660Carbonate IonHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 242723Methyl 6-chloropicolinateHCID 226370253,4-Dimethoxyphenylboric acid

Product 1

HCID 22931007Methyl 6-(3,4-dimethoxyphenyl)pyridine-2-carboxylate

Sources & evidence

ORD record
ord-91c170a552b94cd785d1064b2be44b78
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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