Hydrochloric Acid → 4-(4-Chlorophenyl)piperidine-4-carbonitrile

HRID 702506Notes

Reaction equation

HRID 702506 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([C:14]#[N:15])([c:16]2[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:24][OH:25].[ClH:23].[O:26]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1>>[NH:8]1[CH2:9][CH2:10][C:11]([C:14]#[N:15])([c:16]2[cH:17][cH:18][c:19]([Cl:22])[cH:20][cH:21]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 312751,4-DioxaneHCID 49760270tert-Butyl 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylate

Product 1

HCID 229935654-(4-Chlorophenyl)piperidine-4-carbonitrile

Sources & evidence

ORD record
ord-0ce7ee808806484cba777b1577dd2b86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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