Methanol → Di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate

HRID 702667Notes

Reaction equation

HRID 702667 reaction equation
[BH3:24].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:21](=[O:22])[OH:23])[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1.[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:30][OH:31]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:21][OH:22])[CH2:10][N:11]([C:14](=[O:15])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 887MethanolHCID 6331BoraneHCID 8028Tetrahydrofuran2×HCID 112559791,4-Di-Boc-piperazine-2-carboxylic acid

Product 1

HCID 22711445Di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate

Sources & evidence

ORD record
ord-65b36e3d524b48e8bac717af0d33fa10
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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