Dimethylformamide → N-[4-methyl-5-(2-thienyl)-1,3-thiazol-2-yl]acetamide

HRID 703012Notes

Reaction equation

HRID 703012 reaction equation
[CH2:34]([Sn:35]([CH2:36][CH2:37][CH2:38][CH3:39])([CH2:40][CH2:41][CH2:42][CH3:43])[c:44]1[s:45][cH:46][cH:47][cH:48]1)[CH2:49][CH2:50][CH3:51].[CH3:12][c:13]1[n:14][c:15]([NH:30][C:31]([CH3:32])=[O:33])[s:16][c:17]1-[c:18]1[s:19][c:20]([S:23]([NH:24][CH2:25][C:26]#[CH:27])(=[O:28])=[O:29])[cH:21][cH:22]1.[I:1][c:2]1[s:3][c:4]([NH:5][C:6](=[O:7])[CH3:8])[n:9][c:10]1[CH3:11].[O:52]=[CH:53][N:54]([CH3:55])[CH3:56]>>[CH3:12][c:13]1[n:14][c:15]([NH:30][C:31]([CH3:32])=[O:33])[s:16][c:17]1-[c:18]1[s:19][cH:20][cH:21][cH:22]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 27793732-(Tri-n-butylstannyl)thiopheneHCID 11998301N-(4-methyl-5-{5-[(prop-2-yn-1-ylamino)sulfonyl]-2-thienyl}-1,3-thiazol-2-yl)acetamideHCID 57417074N-(5-Iodo-4-methyl-2-thiazolyl)acetamide

Product 1

HCID 11993489N-[4-methyl-5-(2-thienyl)-1,3-thiazol-2-yl]acetamide

Sources & evidence

ORD record
ord-39472249e00b44c38189866a4ccabfb7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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