1-Methylpiperazine → HCID 57426886, compound

HRID 703085Notes

Reaction equation

HRID 703085 reaction equation
[Cl:1][C:2]1[C:11]([N+]([O-])=O)=[C:10]2[C:5]([C:6](=O)[C:7]([C:21]([OH:23])=[O:22])=[CH:8][N:9]2C2C=CC=CC=2)=[CH:4][C:3]=1F.CN1CCNCC1>>[ClH:1].[N:9]1[C:10]2[C:5](=[CH:4][CH:3]=[CH:2][CH:11]=2)[CH:6]=[C:7]([C:21]([OH:23])=[O:22])[CH:8]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 13733144HCID 13733144, compound

Product 1

HCID 57426886HCID 57426886, compound

Procedure

The synthesis is carried out analogously to Example 1 (2 hours reflux). 7-Chloro-6-fluoro-1,4-dihydro-4-oxo-8-nitro-1-phenyl-quinoline-3-carboxylic acid and N-methylpiperazine are used as the starting substances. The quinoline-3-carboxylic acid hydrochloride (I) (R=C6H5, X1 =NO2, X2 =F, A=4-methyl-1-piperazinyl) obtained as the reaction product has a melting point >300° C. (with decomposition). Melting point of the betaine: 240°-245° C.

Workup

  1. temperatureThe synthesis is carried out analogously to Example 1 (2 hours reflux)

Sources & evidence

ORD record
ord-e9c6f7fb4d554f9dadbefac485df7d9b
Source dataset
uspto-grants-1991_01
Patent number
US04981854

Reaction notes

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