Triethylamine → HCID 15056295, compound

HRID 703096Notes

Reaction equation

HRID 703096 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[C:9]([SH:11])[CH:8]=[C:7]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[OH:16])([CH3:4])[CH3:3].[O:17]=[C:18]([N:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1)[CH:19]=[CH2:20].C(N(CC)CC)C>CO>[CH3:4][C:2]([C:5]1[CH:10]=[C:9]([S:11][CH2:20][CH2:19][C:18]([N:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)=[O:17])[CH:8]=[C:7]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[OH:16])([CH3:1])[CH3:3]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 703702,6-Di-tert-butyl-4-mercaptophenolHCID 98723Acryloylmorpholine

Product 1

HCID 15056295HCID 15056295, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Following the procedure of Example 4, 2,6-bis-(1,1-dimethylethyl)4-mercaptophenol (2.38 g, 0.01 mole) and (1-oxo-2-propenyl)morpholine(1.41 g, 0.01 mole) in methanol (75 ml) were combined with triethylamine (1.5 ml) and stirred for 12 hours at room temperature. The solvent was evaporated under a nitrogen stream leaving an orange oil which was chromatographed over silica. The product was recrystallized from a mixture of hexane, ethyl ether and methanol and the resu-ting white solid dried to yield the title compound, m.p. about 136.5°-137.5° C.

Workup

  1. customThe solvent was evaporated under a nitrogen stream
  2. customleaving an orange oil which
  3. customwas chromatographed over silica
  4. customThe product was recrystallized from a mixture of hexane, ethyl ether and methanol
  5. customthe resu-ting white solid dried

Sources & evidence

ORD record
ord-9869c795a2a24c7a8601fa22a5f051d1
Source dataset
uspto-grants-1991_01
Patent number
US04981853

Reaction notes

Loading…