N-Methylhydrazinecarbothioamide → 2-isonicotinoyl-N-methylhydrazinecarbothioamide

HRID 703121Notes

Reaction equation

HRID 703121 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][C:5]([C:8](Cl)=[O:9])=[CH:4][CH:3]=1.[CH3:11][NH:12][C:13](=[S:16])[NH:14][NH2:15]>N1C=CC=CC=1>[N:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:15][NH:14][C:13]([NH:12][CH3:11])=[S:16])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2723853N-MethylhydrazinecarbothioamideHCID 12262826Isonicotinoyl chloride hydrochloride

Product 1

HCID 28240222-isonicotinoyl-N-methylhydrazinecarbothioamide

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-Pyridoyl chloride hydrochloride (10.0 g, 5.62×10-2 mole) and 4-methylthiosemicarbazide (5.91 g, 5.62×10-1 mole) were stirred at room temperature in pyridine (150 ml). After stirring overnight, the pyridine was evaporated at reduced pressure and the concentrate was washed with H2O. The undissolved product was collected by filtration and dried by suction.

Workup

  1. customthe pyridine was evaporated at reduced pressure
  2. washthe concentrate was washed with H2O
  3. filtrationThe undissolved product was collected by filtration
  4. customdried by suction

Sources & evidence

ORD record
ord-928abee5334b49859c606e0c7e7bfe8b
Source dataset
uspto-grants-1991_01
Patent number
US04981863

Reaction notes

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