HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminocarbonylphenylboronic acid → 1,1-dimethylethyl 7-[4-(amino-carbonyl)phenyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminocarbonylphenylboronic acid | HCID 2737811 | — |
| Reactant | tert-butyl 7-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 21250582 | — |
| Product | 1,1-dimethylethyl 7-[4-(amino-carbonyl)phenyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate | HCID 58276363 | — |
Reaction Steps
The title compound was prepared from 1,1-dimethylethyl 7-{[(trifluoromethyl)sulfonyl]oxy}-3,4-dihydro-2(1H)-isoquinoline carboxylate (Ex V-17) and 4-(aminocarbonyl)-phenyl boronic acid according to the procedure described for I-VII-9. Tan solid; LC/MS (method A) 2.62 min; m/z 353 (M+H, 75%), 297 ([M-C4H8]+H, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822518B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-08c9944d32644cfc9e1cabe32a40c285 |
| Source note | uspto-grants-2014_09 |