Methanol → N,N'-dibutyloxamide

HRID 703244Notes

Reaction equation

HRID 703244 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].[CH3:6][OH:7]>>[CH2:1]([NH:5][C:6]([C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])=[O:7])=[O:7])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 887Methanol2×HCID 8007Butylamine

Product 1

HCID 352186N,N'-dibutyloxamide

Procedure

The temperature is brought to 5° C. with an ice-bath and a solution of n-butyl-amine (25 ml, 0.253 mol) in anhydrous methyl alcohol (25 ml) is dripped in. The reaction is exothermic and dripping is adjusted to keep the temperature below 10°-12° C. When all the methyl alcohol solution of the amine has been added, the reaction mixture has a jelly appearance.

Workup

  1. customThe temperature is brought to 5° C. with an ice-bath
  2. customthe temperature below 10°-12° C

Sources & evidence

ORD record
ord-cd03387333f7441fa7bd71219a767b90
Source dataset
uspto-grants-1991_01
Patent number
US04981963

Reaction notes

Loading…