Hydrochloric Acid → HCID 86744465, compound

Participants

Reaction Steps

To 10.65 g (42.43 mmole) of methyl (2S, 3R)-2-(N-benzoylamino)methyl-3-hydroxybutanoate was added 70 ml of a 10% hydrochloric acid aqueous solution at room temperature to form a solution. The solution was heated at reflux for 4.5 hours and then allowed to cool to room temperature. The precipitated benzoic acid was separated by filtration, and the filtrate was washed twice with 100 ml portions of toluene. The aqueous layer was concentrated under reduced pressure to obtain 6.67 g (yield: 93%) of (2S, 3R)-2-aminomethyl-3-hydroxybutanoic acid hydrochloride.

Provenance & Evidence