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To 10.65 g (42.43 mmole) of methyl (2S, 3R)-2-(N-benzoylamino)methyl-3-hydroxybutanoate was added 70 ml of a 10% hydrochloric acid aqueous solution at room temperature to form a solution. The solution was heated at reflux for 4.5 hours and then allowed to cool to room temperature. The precipitated benzoic acid was separated by filtration, and the filtrate was washed twice with 100 ml portions of toluene. The aqueous layer was concentrated under reduced pressure to obtain 6.67 g (yield: 93%) of (2S, 3R)-2-aminomethyl-3-hydroxybutanoic acid hydrochloride.

1. customto form a solution
2. temperatureThe solution was heated
3. temperatureat reflux for 4.5 hours
4. customThe precipitated benzoic acid was separated by filtration
5. washthe filtrate was washed twice with 100 ml portions of toluene
6. concentrationThe aqueous layer was concentrated under reduced pressure