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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 70329Generated: October 25, 2026

(3-Carbamoylphenyl)boronic acid → 4'-(1,3-Dioxolan-2-yl)-3'-(trifluoromethyl)-3-biphenylcarboxamide

https://huagongshe.com/reaction/70329

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Carbamoylphenyl)boronic acidHCID 2737814—
Reactant2-[4-Iodo-2-(trifluoromethyl)phenyl]-1,3-dioxolaneHCID 58276681—
SolventToluene ethanolHCID 21863594—
Product4'-(1,3-Dioxolan-2-yl)-3'-(trifluoromethyl)-3-biphenylcarboxamideHCID 67159994—

Reaction Steps

The title compound was prepared from 3-(aminocarbonyl)phenyl boronic acid and 2-[4-iodo-2-(trifluoromethyl)phenyl]-1,3-dioxolane (I-IX-7) according to the procedure described for IX-10, using PhMe/EtOH (4:1) as organic cosolvents. Colorless solid. LC/MS (method A) 2.38 min; m/z 338 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822518B2
Source datasetuspto-grants-2014_09
ORD IDord-46ac662b190145d0b275375fff7109d3
Source noteuspto-grants-2014_09