反应详情

温度

50 °C

A mixture of 23 g of 1-(2-hydroxy-5-tetradecylphenyl)ethanone, 5 g of 5% palladium on carbon catalyst, 10 ml of concentrated hydrochloric acid, 100 ml of water and 100 ml of glacial acetic acid was warmed to 50° C. and then hydrogenated in a Parr apparatus for 24 hours. This mixture was filtered, the solvent removed ad the residue dissolved in ether. The ether solution was washed with water, then a small amount of dilute aqueous sodium bicarbonate and dried. The residue was purified by HPLC, giving 16 g of the desired compound, mp 45.5°-46.5° C.

1. filtrationThis mixture was filtered
2. customthe solvent removed ad the residue
3. dissolutiondissolved in ether
4. washThe ether solution was washed with water
5. dry with materiala small amount of dilute aqueous sodium bicarbonate and dried
6. customThe residue was purified by HPLC