Hydrochloric Acid → 8-Amino-3-hydroxyoctanamide hydrochloride

HRID 703380Notes

Reaction equation

HRID 703380 reaction equation
C(OC([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([OH:22])[CH2:18][C:19]([NH2:21])=[O:20])=O)C1C=CC=CC=1.[ClH:23]>CO.[C].[Pd]>[ClH:23].[NH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH:17]([OH:22])[CH2:18][C:19]([NH2:21])=[O:20]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 134572918-Benzyloxycarbonylamino-3-hydroxyoctanamide

Product 1

HCID 221498928-Amino-3-hydroxyoctanamide hydrochloride

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of 1.04 g (3.2 mmoles) of 8-benzyloxycarbonylamino- 3-hydroxyoctanamide in 20 ml of methanol were added 3.2 ml of 1N hydrochloric acid and 200 mg of 10% palladium-carbon. The mixture was stirred under a hydrogen stream at room temperature for 3 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness to yield 670 mg of 8-amino-3-hydroxyoctanamide hydrochloride.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness

Sources & evidence

ORD record
ord-583d5b417ce4495b84f54f3f43326fc2
Source dataset
uspto-grants-1991_01
Patent number
US04983328

Reaction notes

Loading…