HCID 13548560, compound → HCID 13548562, compound

HRID 703448Notes

Reaction equation

HRID 703448 reaction equation
[O:1]=[C:2]1[CH:11]=[C:10]([CH2:12][C:13](OC)=[O:14])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1>[Pt]>[OH:14][CH2:13][CH2:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2](=[O:1])[CH:11]=1.[OH:14][CH2:13][CH2:12][CH:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2](=[O:1])[CH2:11]1

Participants

4

Reactant 1

HCID 13548560HCID 13548560, compound

Product 2

HCID 13548562HCID 13548562, compoundHCID 14624972(+/-)-4-(2-hydroxyethyl)-3,4-dihydro-2(1H)-quinolinone

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

4-(2-Hydroxyethyl)-2(1H)-quinolinone is prepared from methyl 2-oxo-1,2-dihydro-4-quinolineacetate (prepared in 3.3.) according to the procedure described in 1.3. It is a solid, melting point 213°-5° C. A catalytic hydrogenation of this compound is performed with Adams+ platinum to obtain (±)-4-(2-hydroxyethyl)-3,4-dihydro-2(1H)-quinolinone.

Sources & evidence

ORD record
ord-4435f4f9499146569e8f85a164d6c4c5
Source dataset
uspto-grants-1991_01
Patent number
US04983607

Reaction notes

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