HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 2-{2-[4-(4-fluorobenzoyl)-piperidin-1-yl]-ethyl}-7-nitro-1-(2H)-phthalazinone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | 4-(4-Fluorobenzoyl)piperidine | HCID 2724440 | — |
| Reactant | 2-(2-chloroethyl)-6,7-dimethoxy-1(2H)-phthalazinone | HCID 15391923 | — |
| Reactant | 2-(2-chloroethyl)-7-nitro-1(2H)-phthalazinone | HCID 22150173 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-{2-[4-(4-fluorobenzoyl)-piperidin-1-yl]-ethyl}-7-nitro-1-(2H)-phthalazinone hydrochloride | HCID 22150159 | — |
Reaction Steps
Working as described in Example 3 but replacing 2-[2-chloroethyl]-6,7-dimethoxy-1(2H)-phthalazinone with an equivalent amount of 2-(2-chloroethyl)-7-nitro-1(2H)-phthalazinone and replacing N-phenyl piperazine with an equivalent amount of 4-(4-fluorobenzoyl)-piperidine, 2-{2-[4-(4-fluorobenzoyl)-piperidin-1-yl]-ethyl}-7-nitro-1-(2H)-phthalazinone hydrochloride is obtained (m.p. 280°-285° C., from ethyl alcohol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04983606 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-c55d85288d68408284aa028bbf823137 |
| Source note | uspto-grants-1991_01 |