HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 2-{3-[4-(4-fluorobenzoyl)-piperidin-1-yl]-propyl}-6,7-dimethoxy-1(2H)-phthalazinone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | (4-Fluorophenyl)(piperazin-1-yl)methanone | HCID 771862 | — |
| Reactant | 2-(2-chloroethyl)-6,7-dimethoxy-1(2H)-phthalazinone | HCID 15391923 | — |
| Reactant | 2-(3-chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone | HCID 22150171 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-{3-[4-(4-fluorobenzoyl)-piperidin-1-yl]-propyl}-6,7-dimethoxy-1(2H)-phthalazinone hydrochloride | HCID 22150148 | — |
Reaction Steps
Working as described in Example 3 but replacing 2-(2-chloroethyl)-6,7-dimethoxy-1(2H)-phthalazinone with an equivalent amount of 2-(3-chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone obtained as described in Example 13, and replacing N-phenylpiperazine with an equivalent amount of 4-(4-fluorobenzoyl)-piperazine, 2-{3-[4-(4-fluorobenzoyl)-piperidin-1-yl]-propyl}-6,7-dimethoxy-1(2H)-phthalazinone hydrochloride is obtained (m.p. 250°-252° C., from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04983606 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-d4ca02ec99a4431e93c2d9d564da5b07 |
| Source note | uspto-grants-1991_01 |