Trifluoroacetic acid → N-(2-{[(2-amino-1,3-thiazol-4-yl)methyl]thio}-5-chlorophenyl)-1-benzofuran-2-sulfonamide

HRID 70349Notes

Reaction equation

HRID 70349 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[S:10]([NH:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[S:21][CH2:22][C:23]1[N:24]=[C:25]([NH:28]C(=O)OC(C)(C)C)[S:26][CH:27]=1)(=[O:12])=[O:11].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:28][C:25]1[S:26][CH:27]=[C:23]([CH2:22][S:21][C:15]2[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=2[NH:13][S:10]([C:2]2[O:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[CH:3]=2)(=[O:12])=[O:11])[N:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86667123Tert-butyl{4-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}thio)methyl]-1,3-thiazol-2-yl}carbamate

Product 1

HCID 86667122N-(2-{[(2-amino-1,3-thiazol-4-yl)methyl]thio}-5-chlorophenyl)-1-benzofuran-2-sulfonamideYield 88%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl {4-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}thio)methyl]-1,3-thiazol-2-yl}carbamate Compound 11 (62 mg, 0.11 mmol), TFA (0.2 ml) in CH2Cl2 (1 ml) was stirred overnight. The solvent was removed in vacuo and the crude product was purified by column chromatography on silica gel (50% ethyl acetate in hexane) to afford the title compound (45 mg, 88%).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe crude product was purified by column chromatography on silica gel (50% ethyl acetate in hexane)

Sources & evidence

ORD record
ord-9f113d2bab3d43af909a1957d4172b9a
Source dataset
uspto-grants-2014_09
Patent number
US08822530B2

Reaction notes

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