反应详情

A mixture of 39.8 g (0.29 mmol) 2,2-difluorocyclopropylacetic acid and 38.5 ml (0.53 mmol) thionyl chloride was heated under reflux for 5 hours. Excess thionyl chloride was distilled and the residue was distilled in vacuo.

1. temperaturewas heated
2. temperatureunder reflux for 5 hours
3. distillationExcess thionyl chloride was distilled
4. distillationthe residue was distilled in vacuo