HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(2,2-Difluorocyclopropyl)acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(2,2-Difluorocyclopropyl)acetic acid | HCID 14458503 | — |
| Product | 2-(2,2-Difluorocyclopropyl)acetyl chloride | HCID 14458504 | — |
Reaction Steps
A mixture of 39.8 g (0.29 mmol) 2,2-difluorocyclopropylacetic acid and 38.5 ml (0.53 mmol) thionyl chloride was heated under reflux for 5 hours. Excess thionyl chloride was distilled and the residue was distilled in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04983630 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-f5129d878a3344f0909abdac7103d77d |
| Source note | uspto-grants-1991_01 |