HRID703548

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10946

2-Chloroacetic anhydride

C4H4Cl2O3

结构：O=c1[nH]c(=O)n([C@H]2C[C@H](OCc3ccccc3)[C@@H](CO)O2)cc1F

HCID10664574

Uridine, 2'-deoxy-5-fluoro-3'-O-(phenylmethyl)-

C16H17FN2O5

PRODUCTS

生成物

结构：O=C(CCl)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1OCc1ccccc1

HCID13715089

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Chloroacetic anhydride was added to a solution of 0.20 g of 3'-O-benzyl-2'-deoxy-5-fluorouridine in 10 ml of pyridine, and the mixture was left to stand at room temperature overnight. Then the same subsequent procedures as in Example 54 were conducted, giving 0.11 g of the title compound as an oil in a yield of 45%.

WORKUP

后处理

waitthe mixture was left