HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetic anhydride → 3'-O-benzyl-5'-O-chloroacetyl-2'-deoxy-5-fluorouridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetic anhydride | HCID 10946 | — |
| Reactant | Uridine, 2'-deoxy-5-fluoro-3'-O-(phenylmethyl)- | HCID 10664574 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3'-O-benzyl-5'-O-chloroacetyl-2'-deoxy-5-fluorouridine | HCID 13715089 | 45% |
Reaction Steps
Chloroacetic anhydride was added to a solution of 0.20 g of 3'-O-benzyl-2'-deoxy-5-fluorouridine in 10 ml of pyridine, and the mixture was left to stand at room temperature overnight. Then the same subsequent procedures as in Example 54 were conducted, giving 0.11 g of the title compound as an oil in a yield of 45%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04983609 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-6348199efce9494699bd22dd4158e889 |
| Source note | uspto-grants-1991_01 |