反应详情

15.4 g of a diastereomer mixture of 2-hexyl-3-hydroxy-(R)-5 [(tetrahydro-2H -pyran-2-yl)oxy]hexadecanoic acid are dissolved in 160 ml of ethanol and 800 mg of toluene-4-sulphonic acid monohydrate are added. The reaction mixture is heated to 55°-60° C. until the reaction has finished. The solvent is removed in vacuo and the residue is dissolved in 160 ml of dichloromethane. The solution is stirred at room temperature for 1 hour. The reaction mixture is evaporated. The material obtained is chromatographed on silica gel. There is obtained tetrahydro-3-hexyl-4-hydroxy-(R)-6-undecyl-2H-pyran-2-one, m.p. 95°-96° C.

1. temperatureThe reaction mixture is heated to 55°-60° C. until the reaction
2. customThe solvent is removed in vacuo
3. dissolutionthe residue is dissolved in 160 ml of dichloromethane
4. customThe reaction mixture is evaporated
5. customThe material obtained
6. customis chromatographed on silica gel