反应详情

Ethyl chloroformate (0.18 ml) was added dropwise to a stirred, ice-cooled solution of benzo[b]thiophene-2-ethanamine (300 mg) in a mixture of chloroform (8 ml) and triethylamine (0.28 ml) under nitrogen and stirring was continued at 0° for 30 min. The solution was evaporated, the residue was treated with water (10 ml), extracted with dichloromethane (3×10 ml) and the combined, dried organic extracts were evaporated to give an oily solid. This was purified by FCC eluting with System B (1:2) to give the title compound (313 mg), m.p. 65°-66°.

1. customThe solution was evaporated
2. additionthe residue was treated with water (10 ml)
3. extractionextracted with dichloromethane (3×10 ml)
4. customdried organic extracts were evaporated
5. customto give an oily solid
6. customThis was purified by FCC
7. washeluting with System B (1:2)