Methyl chloroacetate → HCID 19829858, compound

HRID 703796Notes

Reaction equation

HRID 703796 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl[CH2:10][C:11]([O:13][CH3:14])=[O:12].C(=O)(O)[O-].[Na+]>>[CH3:14][O:13][C:11](=[O:12])[CH2:10][NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([I:1])[CH:3]=1

Participants

4

Reactant 3

HCID 7295Methyl chloroacetateHCID 122713-IodoanilineHCID 516892Sodium Bicarbonate

Product 1

HCID 19829858HCID 19829858, compoundYield 150.5%

Procedure

3-Iodoaniline (40.0 g), methyl chloroacetate (37.12 g) and sodium bicarbonate (30.75 g) were treated according to the method of Intermediate 5 to give an oil (ca. 80 g), a sample of which (1.2 g) was purified by FCC eluting with System A (7:3) to give the title compound (0.8 g) as a solid, m.p. 83°.

Sources & evidence

ORD record
ord-937b5577d3b141169342e52e5b3069e5
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

Loading…