Methyl chloroacetate → HCID 23001581, compound

HRID 703799Notes

Reaction equation

HRID 703799 reaction equation
Cl.[CH2:2]([O:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[CH2:18][C:19]([O:21][CH3:22])=[O:20].C(=O)(O)[O-].[Na+]>C(#N)C>[CH3:22][O:21][C:19](=[O:20])[CH2:18][NH:14][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:2][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=2)=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 7295Methyl chloroacetateHCID 516892Sodium BicarbonateHCID 27238314-Benzyloxyaniline hydrochloride

Product 1

HCID 23001581HCID 23001581, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-Benzyloxyaniline hydrochloride (70 g), methyl chloroacetate (49 ml) and sodium bicarbonate (75 g) in dry acetonitrile (200 ml) were heated at reflux for 6.5 h. Work up according to the method of Intermediate 7 gave a solid which was recrystallised from chloroform-hexane to give the title compound (55 g), m.p. 106°-107°.

Workup

  1. temperatureat reflux for 6.5 h
  2. customgave a solid which
  3. customwas recrystallised from chloroform-hexane

Sources & evidence

ORD record
ord-6f59f72d564b4a67b4a000fd6699fe66
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

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