3-Propylaniline → HCID 19829931, Verbindung

HRID 703808Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 703808
[CH2:1]([C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+].Cl[CH2:17][C:18]([O:20][CH3:21])=[O:19]>CCOCC>[CH3:21][O:20][C:18](=[O:19])[CH2:17][NH:7][C:6]1[CH:8]=[CH:9][CH:10]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:5]=1

Komponenten

5

Edukt 3

HCID 60563-PropylanilineHCID 7295Methyl chloroacetateHCID 516892Sodium Bicarbonate

Produkt 1

HCID 19829931HCID 19829931, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 3-propylaniline (20 g), sodium bicarbonate (24.9 g) and methyl chloroacetate (24.0 g) were stirred under nitrogen at 80°-90° for 24 h. The cooled reaction mixture was poured into ether (100 ml) and filtered. The filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml), then dried and concentrated in vacuo. The oily product (21.2 g) was distilled to give the title compound as a liquid, b.p. 160° at 0.35 mmHg, which solidified to give a low melting solid (16.1 g).

Aufarbeitung

  1. customThe cooled reaction mixture
  2. filtrationfiltered
  3. washThe filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml)
  4. customdried
  5. concentrationconcentrated in vacuo
  6. distillationThe oily product (21.2 g) was distilled

Quellen und Nachweise

ORD-Eintrag
ord-5ececdb4c7464b4fa84b2a2e2cfb8931
Quelldatensatz
uspto-grants-1991_01
Patentnummer
US04985427

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