反应详情

A mixture of 3-propylaniline (20 g), sodium bicarbonate (24.9 g) and methyl chloroacetate (24.0 g) were stirred under nitrogen at 80°-90° for 24 h. The cooled reaction mixture was poured into ether (100 ml) and filtered. The filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml), then dried and concentrated in vacuo. The oily product (21.2 g) was distilled to give the title compound as a liquid, b.p. 160° at 0.35 mmHg, which solidified to give a low melting solid (16.1 g).

1. customThe cooled reaction mixture
2. filtrationfiltered
3. washThe filtrate was washed with water (100 ml), dilute hydrochloric acid (100 ml) and water (100 ml)
4. customdried
5. concentrationconcentrated in vacuo
6. distillationThe oily product (21.2 g) was distilled