Methyl Isocyanate → HCID 20074988, compound

HRID 703816Notes

Reaction equation

HRID 703816 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([N:9]([CH2:11][C:12](OC)=[O:13])[NH2:10])[CH:6]=[CH:7][CH:8]=1.[CH3:18][N:19]=[C:20]=[O:21].C[O-].[Na+]>CO>[CH3:18][N:19]1[C:12](=[O:13])[CH2:11][N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:16])[F:17])[CH:4]=2)[NH:10][C:20]1=[O:21]

Participants

5

Reactant 3

HCID 12228Methyl IsocyanateHCID 10942334Sodium MethoxideHCID 19829854HCID 19829854, compound

Product 1

HCID 20074988HCID 20074988, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl [1-[3-(trifluoromethyl)phenyl]hydrazino]acetate (5 g) was treated with methyl isocyanate (3.05 ml) and then with sodium methoxide in methanol (60 ml; from sodium (1.16 g)) according to the method of Example 1. The product was purified by FCC eluting with System A (19:1) to give a solid, which was crystallised from System B to give the title compound (1.3 g), m.p. 163°-165°.

Workup

  1. customThe product was purified by FCC
  2. washeluting with System A (19:1)
  3. customto give a solid, which
  4. customwas crystallised from System B

Sources & evidence

ORD record
ord-bec18a5408354f2c9d6ce096a0564069
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

Loading…