Methyl Isocyanate → HCID 20074988, compound

Participants

Reaction Steps

Methyl [1-[3-(trifluoromethyl)phenyl]hydrazino]acetate (5 g) was treated with methyl isocyanate (3.05 ml) and then with sodium methoxide in methanol (60 ml; from sodium (1.16 g)) according to the method of Example 1. The product was purified by FCC eluting with System A (19:1) to give a solid, which was crystallised from System B to give the title compound (1.3 g), m.p. 163°-165°.

Provenance & Evidence