Methyl Isocyanate → HCID 20074946, compound

HRID 703818Notes

Reaction equation

HRID 703818 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]([CH2:11][C:12]([O:14]C)=O)[NH2:10])=[CH:5][CH:4]=1.[CH3:16][N:17]=[C:18]=[O:19].C[O-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:11][C:12](=[O:14])[N:17]([CH3:16])[C:18](=[O:19])[NH:10]2)=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 12228Methyl IsocyanateHCID 10942334Sodium MethoxideHCID 54130144HCID 54130144, compound

Product 1

HCID 20074946HCID 20074946, compound

Procedure

Methyl [1-(4-methoxyphenyl)hydrazino]acetate (1.50 g) was treated with methyl isocyanate (0.85 ml) and then with sodium methoxide (from sodium (0.33 g) in methanol (15 ml)) according to the method of Example 1. The product was purified by recrystallisation from ethyl acetate to give the title compound (703 mg), m.p. 179°-181°, t.l.c. (ether) Rf 0.5.

Workup

  1. customThe product was purified by recrystallisation from ethyl acetate

Sources & evidence

ORD record
ord-59beabe91c7046c4aea733ef5fa260f6
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

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