Methyl Isocyanate → HCID 20074969, compound

HRID 703821Notes

Reaction equation

HRID 703821 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]([CH2:17][C:18]([O:20]C)=O)[NH2:16])=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][N:23]=[C:24]=[O:25].C[O-].[Na+]>>[CH3:22][N:23]1[C:18](=[O:20])[CH2:17][N:15]([C:12]2[CH:11]=[CH:10][C:9]([O:8][CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:14][CH:13]=2)[NH:16][C:24]1=[O:25]

Participants

4

Reactant 3

HCID 12228Methyl IsocyanateHCID 10942334Sodium MethoxideHCID 53808377HCID 53808377, compound

Product 1

HCID 20074969HCID 20074969, compound

Procedure

Methyl [1-[4-(phenylmethoxy)phenyl]hydrazino]acetate (0.73 g) was treated with methyl isocyanate (0.5 ml) and then with sodium methoxide solution (3.5 ml). The product was recrystallised from tetrahydrofuran-hexane to give the title compound (0.56 g), m.p. 224°-227°, t.l.c. (ethyl acetate) Rf 0.55.

Workup

  1. customThe product was recrystallised from tetrahydrofuran-hexane

Sources & evidence

ORD record
ord-24ec6dd0ac4e41e598fa5e0b41630c98
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

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