Hydrochloric Acid → HCID 20074944, compound

HRID 703825Notes

Reaction equation

HRID 703825 reaction equation
CC(C)([O-])C.[K+].[CH3:7][NH:8][C:9]([NH:11][N:12]([CH2:19][C:20]([O:22]C)=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10].Cl>C(C(C)=O)C(C)C>[CH3:7][N:8]1[C:20](=[O:22])[CH2:19][N:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[NH:11][C:9]1=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23665647Potassium tert-butoxideHCID 54122834HCID 54122834, compound

Product 1

HCID 20074944HCID 20074944, compoundYield 80.1%

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

Potassium t-butoxide (11.33 g) was added over 12 min. to a stirred suspension of methyl [2-[(methylamino)carbonyl]-1-phenylhydrazino]-acetate (20.0 g) in methyl isobutyl ketone (200 ml) under nitrogen at 24°-31°. After stirring for 30 min., 1M hydrochloric acid (200 ml) was added at 15°-20°. The resultant suspension was cooled to 0°-5° for 30 min., and the solid was filtered off, washed with water (100 ml) followed by methyl isobutyl ketone (100 ml) and dried in vacuo to give the title compound (13.86 g).

Workup

  1. filtrationthe solid was filtered off
  2. washwashed with water (100 ml)
  3. customdried in vacuo

Sources & evidence

ORD record
ord-ec7b831c8fa64533b4d6df74b9589d19
Source dataset
uspto-grants-1991_01
Patent number
US04985427

Reaction notes

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