反应详情

A mixture of 12.2 g of the thus obtained 2-benzylthio-7-chloro-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one and 124 g of 57% hydroiodic acid was heated to 100°-105° C. and stirred for 4 hours. After cooling, the mixture was filtered and the solid was washed with water and dissolved in chloroform. The organic layer was washed with a sodium hydrogen carbonate aqueous solution, a sodium thiosulfate aqueous solution and water, and dried over anhydrous sodium sulfate. The solvent was distilled off and thus 13.9 g of 55% pure 2-benzylthio-7-iodo-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. Yield 48%.

1. temperaturewas heated to 100°-105° C.
2. temperatureAfter cooling
3. filtrationthe mixture was filtered
4. washthe solid was washed with water
5. dissolutiondissolved in chloroform
6. washThe organic layer was washed with a sodium hydrogen carbonate aqueous solution
7. dry with materiala sodium thiosulfate aqueous solution and water, and dried over anhydrous sodium sulfate
8. distillationThe solvent was distilled off