Butyl bromide → HCID 67842082, compound

HRID 703846Notes

Reaction equation

[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]2[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]2[CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=2)=[CH:5][CH:4]=1.[CH2:25](Br)[CH2:26][CH2:27][CH3:28]>>[ClH:1].[CH2:25]([N:12]1[CH2:13][CH2:14][C@@H:9]([C:6]2[CH:5]=[CH:4][C:3]([F:2])=[CH:8][CH:7]=2)[C@H:10]([CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[CH:21][CH:22]=2)[CH2:11]1)[CH2:26][CH2:27][CH3:28]

Participants

Reactant 2

HCID 8002Butyl bromide

HCID 67842117HCID 67842117, compound

Product 1

HCID 67842082HCID 67842082, compound

Procedure

(-)-trans-1-butyl-4-(4-fluorophenyl)-3-(4-methoxyphenoxy-methyl)-piperidine hydrochloride M.p. 163-165° C. was prepared exactly as described in Example 1 from (-)-trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxymethyl)-piperidine hydrochloride and butyl bromide by refluxing for 120 hours.

Workup

temperatureby refluxing for 120 hours

Sources & evidence

ORD record: ord-6e87f5efa2a8477d8ba02a58a10e5af3
Source dataset: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04985446

Reaction notes

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