反应详情

A suspension of 23.2 g. (0.1 mole) 7-acetamido-1,2,3,4-tetrahydro-4,4-dimethylquinolin-2-one, 200 ml. ethanol and 20 ml. concentrated hydrochloric acid is boiled under reflux until dissolving is complete. The pH value is then adjusted with ammonia to 8, the reaction mixture is extracted three times with dichloromethane and the organic phase is dried over anhydrous sodium sulphate and freed from solvent. Yield 13.1 g. (69% of theory); m.p. 161°-163° C.

1. additionA suspension of 23.2 g
2. temperatureunder reflux
3. dissolutionuntil dissolving
4. extractionthe reaction mixture is extracted three times with dichloromethane
5. dry with materialthe organic phase is dried over anhydrous sodium sulphate