反应详情

To a solution of 20 g (96 mmol) of 2,5-dimethoxy-3,4,6-trimethylbenzaldehyde in 200 ml of ethanol, 1.8 g (47.6 mmol) of sodium boronhydride was added and stirred for 30 minutes. To the reaction mixture saline was added, and the product was extracted with ethyl acetate. The extract was washed with water and dried, from which the solvent was evaporated off under reduced pressure. The residue was crystallized from isopropyl ether, to give 18.6 g (92.1%) of 2,5-dimethoxy-3,4,6-trimethylbenzylalcohol. m.p. 121°-122° C.

1. additionTo the reaction mixture saline was added
2. extractionthe product was extracted with ethyl acetate
3. washThe extract was washed with water
4. customdried, from which the solvent
5. customwas evaporated off under reduced pressure
6. customThe residue was crystallized from isopropyl ether